REACH Côte d’Ivoire is an implementation research project to evaluate the scale-up requirements of azithromycin MDA for children aged 1–11 months.
Type of study
Implementation research
Objectives
Primary objective:
Apply an implementation science framework to systematically evaluate what is required to bring to scale bi-annual mass drug administration (MDA) of single-dose azithromycin for children age 1 to 11 months in high child mortality settings using the existing MDA platforms.
Secondary objectives:
Monitor trends in antimicrobial resistance (AMR) and trends in under-5 mortality in targeted health districts (HD) using existing systems where possible.
Study design
Implementation research (collection of routine monitoring data from MDAs combined with post-MDA research surveys and periodic bio-behavioral AMR surveillance surveys).
The study is using the RE-AIM implementation science framework to:
• Examine the extent to which activities are carried out as planned (adoption, implementation).
• Estimate coverage of the intervention’s target population (reach) with azithromycin.
• Document trends in under-5 mortality in targeted districts (effectiveness) and trends in AMR.
• Document successes, challenges, and costs to inform sustainability (maintenance).
Study location and population
8 regions where infant mortality is greater than 60/1,000 births.
Children aged 1 to 11 months (approximately 160,000) living in targeted health districts, parents/caregivers of eligible children, and MDA implementers: community drug distributors and supervisors; national and regional stakeholders.
Study schedule
Start date: June 2021 (preceded by a pilot study in one district that began in November 2019)
End date: April 2024
Anticipated date key findings will become available:
Results of the MDAs and of the post-MDA research activities will be available as soon as completed. Final results are anticipated by April 2024.
Decisions and policies informed by data:
Feasibility and acceptability to scale up the intervention (what does it take to bring to scale this intervention, at what costs and potential coverage of target population).
Relevant publications: In progress
Study personnel and partners
Study PI: Dr. Lisa DULLI
Co-PI: Dr. Fatoumata TRAORE-TOURE
National Program for the Fight Against Neglected Tropical Diseases, Department of Information Technology and Health Information, Pasteur Institute of Côte d’Ivoire, National Nutrition Program.
